NEURAVOID

Rodent hippocampus. The yellow label identifies CA1 principal neurons (Wfs1), the blue label identifies CA2 principal neurons (Rgs14) and the magenta label identifies DG and CA3 principal neurons (tdTomato). Scale bar: 250um.

Objective

Post-traumatic stress disorder (PTSD) is the fourth most prevalent psychiatric diagnosis and is characterized by a high-rate of treatment resistance and inter-individual variability, with heightened prevalence and severity amongst women. Our work aims at optimizing treatment response across patients suffering from PTSD. In an effort to adhere with SABV-based policies (sex as a biological variable), all experiments carried out in the lab will include 50% male and 50% female mice. We will monitor discrete sets of behavioral parameters in order to detect subtle variations reflecting different behavioral strategies across sexes.